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The 4 mg arm landed near the territory that semaglutide occupies, the 8 mg arm matched what tirzepatide achieves at its top dose, and the 12 mg arm went somewhere no single or dual agonist had reached in a trial of that size

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Many studies have reported the reduced NO bioavailability in the diabetic kidney due to hyperglycemia, advanced glycation end-products, uric acid, and oxidative stress (Khosla et al., 2005)